PI-3065
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
PI-3065是一种选择性的p110δ激酶小分子抑制剂，Ki值和IC50值分别为1.5 nM和5 nM[1]。
据报道，PI-3065选择性地抑制p110δ激酶，作用于p110δ、p110α、p110β和p110γ，Ki值分别为1.5 nM、110 nM、130 nM和940 nM，IC50值分别为5 nM、910 nM、600 nM 和>10000 nM。此外，PI-3065还抑制4T1肿瘤的生长和转移。PI-3065还延长存活，减少宏观转移和其它疾病相关病症的发生率[1]。
参考文献：
[1] Ali K1, Soond DR2, Pi?eiro R1, Hagemann T3, Pearce W4, Lim EL5, Bouabe H5, Scudamore CL6, Hancox T7, Maecker H8, Friedman L8, Turner M5, Okkenhaug K9, Vanhaesebroeck B1. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 19;510(7505):407-11. doi: 10.1038/nature13444. Epub 2014 Jun 11.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 506.64 |
| Cas No. | 955977-50-1 |
| Formula | C27H31FN6OS |
| Solubility | ≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 4-(6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine |
| SDF | Download SDF |
| Canonical SMILES | FC(C=CC1=C2C=CN1)=C2C3=NC4=C(SC(CN5CCN(CC6CC6)CC5)=C4)C(N7CCOCC7)=N3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
