HCV Protease
Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.
- A8898 HZ-1157Summary: HCV NS3/4A蛋白酶抑制剂
- A5618 Daclatasvir (BMS-790052)Target: HCV ProteasesSummary: HCV NS5A抑制剂
- A3864 TegobuvirSummary: HCV RNA 复制抑制剂
- A3820 Simeprevir1 CitationTarget: HCV ProteasesSummary: HCV NS3/4A蛋白酶抑制剂
- A3655 NesbuvirTarget: Nonstructural protein 5B (NS5B)Summary: NS5B聚合酶选择性抑制剂
- A3643 NarlaprevirSummary: NS3蛋白酶抑制剂
- A3261 BoceprevirSummary: HCV蛋白酶抑制剂
- A3257 BMS-790052 dihydrochlorideSummary: HCV NS5A抑制剂
- A3217 BalapiravirSummary: 聚合酶抑制剂,抗HCV
- A3195 Asunaprevir (BMS-650032)2 CitationSummary: NS3蛋白酶抑制剂