HER2
HER2 is a member of the epidermal growth factor. It initiates the EGF downstream cascade by forming a heterodimer with other ligand-bound EGF receptor. It is associated with breast and ovarian cancers.
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B5827 PoziotinibSummary: pan-HER抑制剂 -
B1544 Tyrphostin AG 879Summary: HER2 抑制剂 -
B1543 Mubritinib (TAK 165)Target: ErbBSummary: HER2/ErbB2有效抑制剂 -
A8528 TAK-285Target: EGFR|HER2Summary: HER2/EGFR(HER1)抑制剂 -
A8322 Neratinib (HKI-272)1 CitationTarget: EGFRSummary: HER2/EGFR抑制剂 -
A2822 AC480 (BMS-599626)Target: EGFRSummary: 有效的HER1/2选择性抑制剂 -
A1835 Pelitinib (EKB-569)Summary: 有效的EGFR不可逆抑制剂 -
A2412 CP-724714Target: VEGFR|PDGFR|Bcr-Abl|Src|EGFR|c-MET|Insulin Receptors|IRG-1RSummary: 有效的HER2选择性抑制剂 -
A8247 Afatinib (BIBW2992)1 CitationTarget: EGFRSummary: EGFR/ HER2抑制剂 -
A8218 Lapatinib2 CitationTarget: ErbBSummary: EGFR/HER2抑制剂