Bromodomain
Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.
- C4229 UMB-32Summary: BET溴结构域BRD4和含有溴结构域的转录因子TAF1和TAF1L的抑制剂
- C4097 NI-57Summary: BRPF蛋白溴结构域的抑制剂
- C3668 GSK6853Summary: BRPF1抑制剂
- C3076 AZD 5153Summary: 可口服的BET蛋白BRD4的二价抑制剂
- B7801 CPI-637Summary: CBP/EP300 bromodomain抑制剂
- B6197 PF-CBP1 hydrochlorideSummary: CBP/p300 bromodomain抑制剂
- B6196 BI-7273Summary: BRD9 bromodomain抑制剂
- B6184 BI-9564Summary: BRD9/7特异性抑制剂
- B6169 I-BRD9Summary: BRD9抑制剂
- B5998 GSK2801Summary: BAZ2A和BAZ2B bromodomains抑制剂