IAP
Inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that suppress apoptosis by binding to and inhibiting caspases 3, 7 and/or 9. Members of IAP family are characterized by a novel baculoviral IAP repeat (BIR) domain (approximate 70 amino acids) in which a conserved cysteine and histidine residues (Cx2Cx6Wx3Dx5Hx6C) represents a novel zinc-binding fold. However, not all proteins with BIR domain qualify to be an IAP family member. The ability to suppress apoptosis is required as well. So far, eight members of human IAP family have been identified, which are divided into three classes, including class I (XIAP, cIAP1, cIAP2, ILP2 and MLIAP), class II (NAIP) and class III (SURVIVIN and BRUCE).
- A3019 AT-406 (SM-406)Summary: IAP抑制剂
- A8815 SM-1648 CitationTarget: Inhibitor of apoptosis proteins (IAP)Summary: 抗癌药
- B4653 BV611 CitationSummary: IAP蛋白抑制剂
- A8235 Embelin中文名: 恩贝酸,恩贝灵Summary: 细胞通透的XIAP抑制剂
- A3891 Triptolide1 Citation中文名: 雷公藤甲素Summary: IL-2/MMP-3/MMP7/MMP19抑制剂
- A3541 LCL1611 CitationTarget: Inhibitor of apoptosis proteins (IAP)Summary: IAPs拮抗剂
- A4224 GDC-01522 CitationTarget: Inhibitor of apoptosis proteins (IAP)Summary: IAP 拮抗剂
- A4221 YM1552 CitationTarget: SurvivinSummary: Survivin抑制剂,细胞凋亡抑制剂
- A4219 Birinapant (TL32711)9 Citation中文名: 比瑞那帕Summary: XIAP/cIAP1拮抗剂