HIV Integrase
Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.
- C4787 EquisetinSummary: HIV-1整合酶抑制剂
- B5856 GSK1349572 sodiuM salt中文名: 度鲁特韦钠盐Summary: 下一代HIV整合酶(IN)抑制剂
- B1122 NelfinavirSummary: HIV-1蛋白酶抑制剂
- A8566 GSK744 (S/GSK1265744)中文名: 卡替拉韦Summary: HIV整合酶抑制剂
- A3653 Nelfinavir Mesylate中文名: 奈非那韦Summary: HIV蛋白酶抑制剂,治疗HIV的抗逆转录病毒药物
- A3461 HIV-1 integrase inhibitorSummary: 用于抗HIV
- A4074 S/GSK1349572中文名: 度鲁特韦Summary: HIV整合酶抑制剂
- A4073 Raltegravir (MK-0518)1 Citation中文名: 拉替拉韦,雷特格韦Target: integraseSummary: HIV-1整合酶抑制剂
- A4071 Fluorouracil (Adrucil)3 Citation中文名: 氟尿嘧啶Target: Thymidylate SynthaseSummary: 胸苷酸合成酶抑制剂,抗肿瘤药物。
- A4070 Elvitegravir (GS-9137)中文名: 埃替格韦Target: HIV IntegrasesSummary: HIV-1整合酶抑制剂