HIV Protease
Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.
- B4950 Darunavir EthanolateSummary: 非肽HIV蛋白酶抑制剂
- A3876 TipranavirSummary: HIV蛋白酶抑制剂
- A3791 Saquinavir mesylateSummary: HIV蛋白酶抑制剂
- A3790 SaquinavirSummary: HIV蛋白酶抑制剂
- A3653 Nelfinavir MesylateSummary: HIV蛋白酶抑制剂,治疗HIV的抗逆转录病毒药物
- A3421 Fosamprenavir Calcium SaltSummary: 抗逆转录病毒蛋白酶抑制剂amprenavir的前药。
- A3253 BMS-6265292 CitationTarget: HIV-1 gp120Summary: HIV-1吸附的抑制剂
- A8201 Amprenavir (agenerase)Summary: HIV-1蛋白酶抑制剂
- A8206 Darunavir2 CitationSummary: HIV-1蛋白酶抑制剂
- A8203 RitonavirSummary: HIV蛋白酶抑制剂