Proteases
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B8508 NSC 185058Summary: ATG4B抑制剂
- B4950 Darunavir Ethanolate中文名: 地瑞那韦Summary: 非肽HIV蛋白酶抑制剂
- A1902 Z-VAD-FMK102 CitationTarget: CaspasesSummary: Pan-Caspase抑制剂。
- C5830 PD 145305Summary: 钙蛋白酶的选择性抑制剂
- C5818 MMP-2 Inhibitor IISummary: MMP-2的不可逆抑制剂
- C5615 MMP-2 Inhibitor ISummary: 基质金属蛋白酶(MMP)-2的可逆抑制剂
- C5598 MMP-2/MMP-9 Inhibitor ISummary: 基质金属蛋白酶-2(MMP-2)和MMP-9的有效抑制剂
- C5589 ChymostatinSummary: 糜蛋白酶样丝氨酸蛋白酶抑制剂
- C5839 Tosyllysine Chloromethyl Ketone (hydrochloride)Summary: 丝氨酸蛋白酶抑制剂
- C5347 Calpain Inhibitor XIISummary: 可逆和选择性钙蛋白酶I抑制剂