Thymidylate Synthase
Thymidylate synthase (TS) is an enzyme catalyzing the sole de novo pathway for the biosynthesis of deoxythymidine monophosphate (dTMP) in which deoxyuridine monophosphate (dUMP) is reductively methylated by 5,10-methylenetetrahydrofolate (CH2H4folate) with the generation of dTMP and dihydrofolate (H2folate). TS has been found in a wide range of sources, including bacteria, bacteriophage, yeast, viruses and vertebrates, where it is usually a dimer consisting of identical subunits (30 to 35 kDa each). However, protozoal TS is a bifunctional protein with dihydrofolate reductase (DHFR) on the same polypeptide chain, where TS and DHFR domains are located on the carboxy terminus and amino terminus respectively.
- B5892 Nolatrexed (AG-337)Summary: 胸苷酸合成酶抑制剂
- B2092 DoxifluridineSummary: 抗肿瘤药5-氟尿嘧啶(5-FU)的口服前药
- A8542 Triflurdine (Viroptic)Summary: 抗疱疹病毒抗病毒药物
- A3707 Pemetrexed disodium hemipenta hydrateSummary: 抗叶酸和抗代谢剂
- A4390 Pemetrexed1 CitationTarget: Thymidylate Synthase|DHFR|GARFTSummary: TS、DHFR、GARFT和AICARFT抑制剂