Elastase
Elastase is a serine protease that catalyzes not only the hydrolysis of peptide bonds of proteins but also the hydrolysis of amides and esters. Although it has similar functions as trypsin and chymotrypsin, elastase preferentially targets the protein elastin catalyzing cleavage at its neutral sites. Two major types of elastase have been identified, including pancreatic elastase and neutrophil elastase (PMN). While he pancreatic elastase is produced initially as an inactive protein requiring the activation by trypsin in the duodenum; PMN is found in relatively high levels in the azurophilic granules of circulating leukocytes and neutrophils. Both types of elastase exhibit similar activities but differ in substrate specificity and inhibitor profile.
- C4325 BAY-678Summary: HNE抑制剂
- C3609 (Z-Ala-Ala-Ala-Ala)2Rh110Summary: 荧光弹性蛋白酶底物
- C3252 Neutrophil Elastase InhibitorSummary: 嗜中性粒细胞弹性蛋白酶抑制剂
- B6189 Sivelestat (ONO-5046)Summary: 中性粒细胞弹性蛋白酶抑制剂
- B4676 GW311616 hydrochlorideSummary: HNE抑制剂
- B4675 GW311616Summary: 人嗜中性粒细胞弹性蛋白酶抑制剂
- B1037 AlvelestatTarget: NESummary: NE抑制剂
- A4431 SSR 69071Summary: HLE抑制剂
- A4430 Sivelestat sodium saltTarget: ElastasesSummary: 白细胞弹性蛋白酶抑制剂
- A4432 ARP 1001 CitationTarget: MMPSummary: MMP-2抑制剂