Proteasome
The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.
- A8172 Dihydroeponemycin1 CitationSummary: 蛋白酶体抑制剂,抗癌剂。
- C4090 HMB-Val-Ser-Leu-VESummary: 20S蛋白酶体的胰蛋白酶样活性抑制剂
- B6026 VR23Target: ProteasomeSummary: 蛋白酶抑制剂
- B4755 PI-1840Summary: 胰凝乳蛋白酶样(CT-L)抑制剂
- A4443 Gliotoxin1 CitationTarget: 20S proteasomal chymotrypsin|Geranylgeranyltransferase I|FarnesyltransferaseSummary: 20S蛋白酶体抑制剂
- A8163 AM 1142 CitationTarget: ProteasomeSummary: 20S蛋白酶体抑制剂
- A1934 Oprozomib (ONX-0912)5 CitationSummary: 蛋白酶体抑制剂
- A1933 Carfilzomib (PR-171)10 Citation中文名: 卡非佐米Target: ProteasomeSummary: 蛋白酶体抑制剂
- A1900 PSISummary: 蛋白酶体抑制剂
- A2614 Bortezomib (PS-341)24 Citation中文名: 硼替佐米Target: ProteasomeSummary: 蛋白酶体抑制剂