Histone Acetyltransferases
Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.
- C5773 CTPBSummary: 组蛋白乙酰转移酶(HAT)p300的选择性激活剂
- C5000 HAT Inhibitor IISummary: 组蛋白乙酰转移酶p300的抑制剂
- C3209 Butyrolactone 3Summary: 组蛋白乙酰转移酶Gcn5抑制剂
- C3208 CPTH2 (hydrochloride)Summary: Gcn5的HAT活性抑制剂
- A8712 MCB-613Target: SrcSummary: 类固醇受体共激活因子(SRC)刺激物
- B4946 Garcinol中文名: 山竹子素Summary: PCAF和p300组蛋白乙酰转移酶(HAT)活性抑制剂
- B4945 IWP 12Summary: PORCN抑制剂
- B4887 RemodelinTarget: NAT10Summary: NAT10抑制剂
- B7739 L002Summary: p300抑制剂
- B7679 (R)-(+)-Etomoxir sodium salt中文名: 乙莫克舍(钠盐)Summary: 肉碱棕榈酰转移酶I(CPT1)抑制剂