DNA Methyltransferase
DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group from the methyl donor, usually S-adenosyl-L-methionine (SAM) for all known DNMTs, to the 5-position of cytosine residues in DNA. In mammals, four members of the DNMT gene family have been identified and designated, DNMT1, DNMT3A, DNMT3B and DNMT3L respectively, in which DNMT1 encodes the maintenance methyltransferase, DNMT3A/3B encode the de novo methyltransferases, and DNMT3L encodes an enzyme without any inherent enzymatic activity. Mammalian DNMTs are involved in transcriptional silencing of several sequence classes and play an important role in maintaining genome stability and genomic integrity.
- C4119 2',3',5'-triacetyl-5-AzacytidineSummary: DNA甲基转移酶抑制剂5-azacytidine的前药形式
- A8191 Nanaomycin A2 CitationSummary: DNMT3B抑制剂
- A1915 Zebularine1 Citation中文名: 泽布拉林Target: DNA Methyltransferases|Cytidine deaminasesSummary: DNA甲基化抑制剂
- A1913 RG 1083 CitationTarget: DNA MethyltransferasesSummary: DNA甲基转移酶抑制剂
- A1912 Lomeguatrib中文名: 罗米鲁曲Target: O6-methylguanine-DNA-methyl-transferase (MGMT)Summary: MGMT抑制剂
- A1907 5-Azacytidine6 Citation中文名: 氮胞苷(5-氮胞苷)Target: DNA MethyltransferasesSummary: DNA甲基转移酶抑制剂
- A1906 Decitabine (NSC127716, 5AZA-CdR)中文名: 地西他滨Summary: 脱氧胞苷类似物,细胞分化诱导剂。
- A4176 Thioguanine中文名: 硫鸟嘌呤Summary: Purine antimetabolite