PPAR
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
- C5671 RB394Summary: 可溶性环氧化物水解酶(sEH)和PPARγ的双重调节剂
- C5572 SR 2595Summary: PPARγ的反向激动剂
- C5435 G3335Summary: PPARγ拮抗剂
- C5557 SR 1824Summary: 非激动剂型PPARγ配体
- C5712 DG-172 (hydrochloride)Summary: PPARβ/δ的口服反向激动剂
- C5631 Glycerophospho-N-Oleoyl EthanolamineSummary: 油酰乙醇酰胺(OEA)的前体
- C5280 3-Thiatetradecanoic AcidSummary: PPAR激活剂
- C5263 LT175Summary: 双重PPARα/γ配体
- C5151 Cetaben中文名: 西他苯Summary: 独特的PPARα非依赖性过氧化物酶体增殖物
- C4892 MCC-555Summary: 噻唑烷二酮类抗糖尿病化合物,一种新型PPARα/γ双配体