KEAP1-Nrf2
The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.
- C5715 NK 252Summary: Nrf2激活剂
- C4733 Sulforaphane中文名: 萝卜硫素Summary: 通过Keap1-Nrf2信号传导的化学预防酶诱导剂
- C4354 CDDO-TFEASummary: Nrf2激活剂
- C3234 2-HBASummary: Keap1-Nrf2-ARE通路中催化解毒反应的酶的间接诱导剂
- B3576 Omaveloxolone (RTA-408)Target: Nrf2Summary: Nrf2激活剂
- B1931 Dimethyl Fumarate中文名: 富马酸二甲酯Summary: Nrf2通路激活剂
- A3335 Curcumin1 Citation中文名: 姜黄素Target: Histone Deacetylases (HDACs)|Nrf2|Histone Acetyltransferases (HATs)|TyrosinasesSummary: Tyrosinase(酪氨酸酶)抑制剂
- A3220 Bardoxolone中文名: 巴多索隆Target: COX|iNOSSummary: 用于治疗慢性肾病,每天一次
- N2172 5,7-dihydroxychromone1 Citation中文名: 5,7-二羟基色酮Target: Nrf2/ARE signal|PPARSummary: Nrf2/ARE信号激活剂和PPARγ激动剂
- N2285 Dimethylfraxetin中文名: 二甲基白蜡树亭,白蜡树素,涔皮素