HSP
Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.
- C4803 ApoptozoleSummary: 热休克蛋白70(Hsp70)抑制剂
- C3212 CCT018159Summary: Hsp90的ATP酶活性抑制剂
- B4571 CH5138303Summary: Hsp90抑制剂
- B3693 NMS-E973Summary: Hsp90抑制剂
- B3593 VER-49009Summary: HSP90抑制剂
- B3592 VER-50589Summary: HSP90抑制剂
- A2213 17-DMAG (Alvespimycin) HCl1 Citation中文名: 阿螺旋霉素盐酸盐Target: HSP90Summary: Hsp90抑制剂
- A3756 RetaspimycinSummary: HSP90抑制剂,抗增殖和抗肿瘤。
- A4388 XL-8881 CitationTarget: HSP90Summary: Hsp90抑制剂
- A4387 VER 1550084 CitationSummary: HSP 70抑制剂