MDM2
The murine double minute 2 (MDM2) is a protein encoded by the mdm2 gene that functions as an E3 ubiquitin ligase to ubiquitinate the p53 tumor suppressor and promotes the proteasomal degradation of p53. Human MDM2 protein is a phosphoprotein of 491 amino acids that inherits the E3 ubiquitin ligase activity from its evolutionarily conserved COOH terminal of RING finger domain (Zinc-binding), a common motif in E3 ligases. Human MDM2 protein mediates monomeric ubiquitination on multiple lysine residues mainly in the COOH terminus of p53 and directly inhibits the transcriptional activity of p53 through binding to the NH2 terminal transactivation domain of p53.
- C4120 SP 141Summary: Mdm2抑制剂
- B6058 (±)-Nutlin-3Summary: MDM2拮抗剂
- B4984 MI-77301 (SAR405838)Summary: 口服MDM2拮抗剂
- B4813 Pifithrin-βSummary: 有效的p53抑制剂
- B4756 YH239-EESummary: p53-MDM2拮抗剂
- A9903 p53/MDM2 Set ISummary: 抑制MDM2-p53相互作用
- A2005 Nutlin-3bTarget: p53-MDM2 interactionSummary: MDM2/p53抑制剂
- A3763 RG73882 CitationSummary: MDM2拮抗剂
- A3762 RG71125 CitationTarget: MDM2Summary: MDM2抑制剂
- A4202 RITA (NSC 652287)Summary: Mdm2-p53和p53泛素化抑制剂