HSP
Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.
- B5848 KNK437Summary: 应激诱导的热休克蛋白合成抑制剂
- B4920 EC 144Target: HSP90Summary: Hsp90抑制剂
- B4797 HSP990 (NVP-HSP990)Target: HSP90Summary: HSP90抑制剂
- B7393 GeduninTarget: HSP90Summary: 天然的Hsp90抑制剂
- B5657 MKT 077Summary: mortalin-2(mot-2)抑制剂
- B7703 TRC 051384Summary: HSP70诱导剂
- B7259 Macbecin ISummary: Hsp90抑制剂
- A2213 17-DMAG (Alvespimycin) HCl1 Citation中文名: 阿螺旋霉素盐酸盐Target: HSP90Summary: Hsp90抑制剂
- A3756 RetaspimycinSummary: HSP90抑制剂,抗增殖和抗肿瘤。
- A4388 XL-8881 CitationTarget: HSP90Summary: Hsp90抑制剂