Histone Demethylases
Histone demethylases are a diverse group of enzymes catalyzing a process to reverse histone methylation, in which methyl (CH3-) groups are removed from instead of being transferred to histone. So far, two evolutionarily conserved histone demethylase families have been identified, including LSD demethylases and JMJC demethylases. LSD1 and LSD2 are two well-established members of LSD demethylase family, which catalyze demethylation through a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. LSD1 has been found to demethylate H3K4mel, H3K4me2, H3K9me1, H3K9me2 and a few non-histone targets; while LSD2 has been found to demethylate only H3K4me1 and H3K4me2. Members of JMJC demethylase family is characterized by containing the catalytic JMJC domain, which demethylate substrates, including H3K4, H3K9, H3K27, H3K36 and H4K20, through a Fe(II)- and α-ketogutarate-dependent dioxygenase reaction.
- A8792 GSK J5 HCl
- A8766 OG-L002 HClSummary: LSD1抑制剂
- C5162 BizineSummary: LSD1抑制剂
- C4247 RN-1 (hydrochloride)Summary: LSD1抑制剂
- C3095 N-OxalylglycineSummary: α-酮戊二酸依赖性酶(包括JMJD2A,JMJD2C和JMJD2E)的细胞渗透性抑制剂
- C3630 Lysine-specific Demethylase Inhibitor (1C)Summary: 赖氨酸特异性去甲基化酶抑制剂
- C3584 PBITSummary: JARID1家族去甲基化酶抑制剂
- B7811 CPI-455 HClSummary: KDM5抑制剂
- B6084 AS8351Summary: 组蛋白去甲基化酶抑制剂
- B5972 2,4-Pyridinedicarboxylic AcidSummary: 组蛋白LSD抑制剂