KW-2478
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
KW-2478是一种新型、强效的非Ansamycin热休克蛋白90（Hsp90）抑制剂，可以克服17-烯丙胺基-17-脱甲基格尔德霉素（17-AAG）低水溶性和肝毒性的不足。KW-2478对各种染色体易位的多发性骨髓瘤（MM）细胞具有很强的抗肿瘤活性，其中，KW-2478抑制与Hsp90受体蛋白降解和IgH易位产物（包括FGFR3，c-Maf和cyclin D1）减少相关的细胞生长与凋亡。最近的研究结果表明，KW-2478能够耗尽Hsp90受体蛋白Cdk9（一种转录激酶）和磷酸化4E-BP1（一种转录抑制剂），从而下调c-Maf和cyclin D1的表达。
参考文献：
Nakashima T, Ishii T, Tagaya H, Seike T, Nakagawa H, Kanda Y, Akinaga S, Soga S, Shiotsu Y. New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells. Clin Cancer Res. 2010; 16(10): 2792-802.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 574.66 |
| Cas No. | 819812-04-9 |
| Formula | C30H42N2O9 |
| Synonyms | KW2478,KW 2478 |
| Solubility | ≥100 mg/mL in DMSO |
| Chemical Name | 2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide |
| SDF | Download SDF |
| Canonical SMILES | CCC1=C(C=C(C(=C1CC(=O)N(CCOC)CCOC)C(=O)C2=CC(=C(C=C2)OCCN3CCOCC3)OC)O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | KW-2478是一种新型的、非Ansamycin和有效的Hsp90抑制剂，IC50值为3.8 nM。 | |||||
| 靶点 | Hsp90 | |||||
| IC50 | 3.8 nM | |||||
化学结构
