Compound 56
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Compound 56，4-[(3-溴苯基)氨基]-6，7-二乙氧基喹唑啉，是表皮生长因子受体酪氨酸激酶有效的、特定的抑制剂（IC50 = 0.006 nM)。它竞争性结合表皮生长因子受体的三磷酸腺苷(ATP)位点。Compound 56能够抑制EGF依赖性的表皮生长因子受体的磷酸化、抑制表皮生长因子受体过表达人类癌细胞株系的增殖和平板的集落生成，并在成纤维细胞过表达表皮生长因子受体中阻止EGF调节的有丝分裂和致癌转换，它还能轻微地抑制人类表皮生长因子受体2(HER2/neu)的酪氨酸激酶。
参考文献：
[1]. Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HD, Fry DW, Kraker AJ, and Denny WA. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.J Med Chem 1966; 39 (1): 267-276.
[2]. Monique Bos, Jhn Mendelsohn, Young-Mee Kim, Joan Albanell, David W. Fry, and Jose Baelga. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res 1997;3:2099-2106.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 388.3 |
| Cas No. | 171745-13-4 |
| Formula | C18H18BrN3O2 |
| Solubility | insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic |
| Chemical Name | N-(3-bromophenyl)-6,7-diethoxyquinazolin-4-amine |
| SDF | Download SDF |
| Canonical SMILES | CCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OCC |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | Compound 56是表皮生长因子受体酪氨酸激酶活性的细胞通透的、可逆的和三磷酸腺苷竞争性的抑制剂。 | |||||
| 靶点 | EGFR | |||||
| IC50 | ||||||
质量控制和MSDS
- 批次:
化学结构
相关生物数据
