ALK inhibitor 2
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ALK抑制剂是潜在抗癌药，其作用于含有间变性淋巴瘤激酶（ALK）变异（如EML4-ALK）的肿瘤[1]。ALK抑制剂2与ALK抑制剂1一样，也是一种新型的、选择性的ALK激酶抑制剂。
体外：ALK抑制剂2 (2-[[5-溴-2-[2-甲氧基-4-(4-甲基哌嗪-1-基)苯胺基]嘧啶-4-基]氨基]-N-甲基苯磺酰胺)是LDK378的化学类似物，是一种强效的ALK抑制剂[2]。
体内：目前还没有动物体内数据。
临床试验：目前ALK抑制剂2仅处在临床前发展阶段，还没有临床数据。
参考文献：
[1] Palmer RH, Vernersson E, Grabbe C, Hallberg B. Anaplastic lymphoma kinase: signalling in development and disease. Biochem J. 2009;420(3):345-61.
[2] Marsilje TH, Pei W, Chen B, Lu W, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013;56(14):5675-90.
| Storage | Store at -20°C |
| M.Wt | 518.03 |
| Cas No. | 761438-38-4 |
| Formula | C23H28ClN7O3S |
| Solubility | Soluble in DMSO |
| Chemical Name | 2-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-N-methylbenzenesulfonamide |
| SDF | Download SDF |
| Canonical SMILES | CNS(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
