CGP60474
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CGP60474是一种强效的细胞周期蛋白依赖性激酶（CDKs）抑制剂，作用于CDK1的IC50值为17 nM[1]，还是一种蛋白激酶C（PKC）抑制剂[1]。
CDKs是调节细胞周期的蛋白激酶家族。PKC在信号转导、细胞增殖和分化中起重要作用[2]。
CGP60474对于PKC的选择性高于其他丝氨酸/苏氨酸和酪氨酸激酶，并表现出与ATP相关的竞争动力学[2]。
参考文献：
[1]. Kuo GH, Deangelis A, Emanuel S, et al. Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. J Med Chem, 2005, 48(14): 4535-4546.
[2]. Stanetty P, Hattinger G, Schnürch M, et al. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J Org Chem, 2005, 70(13): 5215-5220
| Storage | Store at -20°C |
| M.Wt | 355.82 |
| Cas No. | 164658-13-3 |
| Formula | C18H18ClN5O |
| Synonyms | CGP-60474;CGP 60474 |
| Solubility | Soluble in DMSO |
| Chemical Name | 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC(=C1)Cl)NC2=NC=CC(=N2)C3=CC(=NC=C3)NCCCO |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
