Rac GTPase fragment
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Rac GTP酶片段的化学式为C46H74N12O14，氨基酸序列为NH2-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH，分子量为1019.15。Rac是GTP酶Rho家族的亚家族，是一种小的信号G蛋白（更具体的GTP酶）。Rac1在各种癌症中的发展中发挥显著作用，包括黑色素瘤(1)和非小细胞肺癌(2)。Rac1是一个小信号G蛋白，更具体地说是GTP酶，分子量约为21 kDa，是GTP酶Rho家族的亚家族。这个家族的成员参与调节各种细胞过程，包括细胞生长的控制和细胞骨架重组，蛋白激酶Rac1的活化是许多细胞过程的多效调节器，包括细胞周期、细胞-细胞粘附、通过肌动蛋白网络的运动以及上皮细胞分化(3)。
Figure1 structure of Rac GTPase 1
Figure2 The Rac GTPase pathway
参考文献：
1. Hodis, E; Watson, IR; Kryukov, GV; Arold, ST; Imielinski, M; Theurillat, JP; Nickerson, E; Auclair, D; Li, L; Place, C; Dicara, D; Ramos, AH; Lawrence, MS; Cibulskis, K; Sivachenko, A; Voet, D; Saksena, G; Stransky, N; Onofrio, RC; Winckler, W; Ardlie, K; Wagle, N; Wargo, J; Chong, K; Morton, DL; Stemke-Hale, K; Chen, G; Noble, M; Meyerson, M; Ladbury, JE; Davies, MA; Gershenwald, JE; Wagner, SN; Hoon, DS; Schadendorf, D; Lander, ES; Gabriel, SB; Getz, G; Garraway, LA; Chin, L (2012 Jul 18). "A landscape of driver mutations in melanoma.". Cell.
2. Stallings-Mann, M. L.; Waldmann, J.; Zhang, Y.; Miller, E.; Gauthier, M. L.; Visscher, D. W.; Downey, G. P.; Radisky, E. S. et al. (2012). "Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression". Science Translational Medicine 4 (142): 142ra95–142ra95.
3. Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1019.15 |
| Formula | C46H74N12O14 |
| Synonyms | H2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH |
| Solubility | ≥101.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| SDF | Download SDF |
| Canonical SMILES | NC(C(C)C)C(NC(CC1=CC=CC=C1)C(NC(CC(O)=O)C(NC(CCC(O)=O)C(NC(C)C(NC(C(NC(CCCNC(N)=N)C(NC(C)C(NC(C(C)C)C(O)=O)=O)=O)=O)C(C)CC)=O)=O)=O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
