切换导航

IRAK inhibitor 4

现货
Catalog No.
A3503
IRAK抑制剂
组合的产品项目
规格价格库存 数量
2mg
¥ 5,360.00
Ship with 10-15 days
5mg
¥ 8,040.00
Ship with 10-15 days

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

Background

IRAK inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].

IRAK-4 belongs to Interleukin-1 Receptor-Associated Kinase, which are key components in the signal transduction pathways. IRAK-4 is an essential signal transducer downstream of interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R) and Toll-like receptors (TLRs). Inhibition of IRAK-4 can modulate its function, thus toning down inflammatory responses. IRAK inhibitor 4 is an indazole inhibitor. As inhibitors of IRAK-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1].

References:
[1] Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh. IRAK-4 Inhibitors for Inflammation. Current Topics in Medicinal Chemistry. 2009, 9: 724-737.

Chemical Properties

StorageStore at -20°C
M.Wt620.66
Cas No.1012104-68-5
FormulaC33H35F3N6O3
SolubilitySoluble in DMSO
Chemical Name1-(4-hydroxycyclohexyl)-N-(3-methylbutyl)-2-[[5-[2-(trifluoromethoxy)phenyl]-1H-indazol-3-yl]amino]benzimidazole-5-carboxamide
SDFDownload SDF
Canonical SMILESCC(C)CCNC(=O)C1=CC2=C(C=C1)N(C(=N2)NC3=NNC4=C3C=C(C=C4)C5=CC=CC=C5OC(F)(F)F)C6CCC(CC6)O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

生物活性

描述 IRAK inhibitor 4是白细胞介素-1受体相关激酶(IRAK,interleukin-1 receptor-associated kinase)抑制剂。
靶点 IRAK          
IC50            

质量控制

质量控制和MSDS

批次:

化学结构

IRAK inhibitor 4