AZ3146
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AZ3146是一种强效的和选择性的单极纺锤体1(Mps1)激酶抑制剂,IC50值为35 nM。AZ3146通过干扰染色体排列以及重写纺锤体组装检查点。
MPS1蛋白激酶在有丝分裂的各个步骤中起到重要作用,包括染色体附着和在中心体的功能。此外,MPS1 蛋白激酶还参与发育调节以及有丝分裂后的多条信号途径。
在细胞培养物中,如果Mps1在进入有丝分裂之前受到AZ3146抑制,这种抑制作用使着丝点取消招募Mad1和Mad2。然而,如果细胞在进入有丝分裂之后用AZ3146处理,Mad1-C-Mad2 轴心复合体保持与着丝点结合,但是O-Mad2未被招募至轴心,AZ3146干扰染色体排列并重写纺锤体组装检查点。
关于体内AZ3146 给药的作用,将通过进行人或小鼠或其他动物模型中的研究提供证据。
参考文献:
1. Hewitt L, Tighe A, Santaguida S, et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. The Journal of cell biology.2010;190(1):25-34.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 452.55 |
Cas No. | 1124329-14-1 |
Formula | C24H32N6O3 |
Synonyms | AZ 3146; AZ-3146 |
Solubility | insoluble in H2O; ≥15.3 mg/mL in EtOH; ≥9.64 mg/mL in DMSO |
Chemical Name | 9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one |
SDF | Download SDF |
Canonical SMILES | CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | AZ3146是一种选择性的Mps1抑制剂,IC50值约为35 nM。 | |||||
靶点 | Mps1 | |||||
IC50 | ~35 nM |
质量控制和MSDS
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