Mps1-IN-2
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Mps1-IN-2是一种有效的\选择性的和ATP竞争性的Mps1激酶抑制剂,其IC50值为145 nM[1].
据报道,在1 μM ATP存在时,Mps1-IN-2可以抑制Mps1激酶活性,其IC50值为145 nM.此外,Mps1-IN-2对Mps1的选择性比对Alk和Ltk酶高1000多倍.Mps1-IN-2结合到Mpa1的ATP结合口袋,在2.74分辨率下,观察到Mps1-IN-2与该激酶铰链区(Glu603)形成氢键.Mps1-IN-2通过直接抑制Mps1,从而废除纺锤体组装检查点(SAC)功能[1].
参考文献:
[1] Kwiatkowski N1, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6(5):359-68. doi: 10.1038/nchembio.345. Epub 2010 Apr 11.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 480.6 |
Cas No. | 1228817-38-6 |
Formula | C26H36N6O3 |
Solubility | Soluble in DMSO |
Chemical Name | 9-cyclopentyl-2-[2-ethoxy-4-(4-hydroxypiperidin-1-yl)anilino]-5-methyl-7,8-dihydropyrimido[4,5-b][1,4]diazepin-6-one |
SDF | Download SDF |
Canonical SMILES | CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(CCC(=O)N4C)C5CCCC5 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |