Verbascoside
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Verbascoside(Acteoside)是羟基酪醇及苯丙糖酯,是PKC和NF-κB的抑制剂[1].
Verbascoside能够通过调节ERK信号通路,减少酪氨酸酶活性和黑色素生物合成,并
抑制霉菌毒素介导的细胞损伤.另外,Verbascoside能够减少RANKL刺激的RAW264.7细胞分化和破骨细胞形成.而且,Verbascoside能够抑制骨髓巨噬细胞(BMMs)中破骨细胞形成,IC50值为4.8 μM.此外,巨噬细胞免疫测定表明,Verbascoside抑制RANKL诱导的p-p38\p-ERK\p-JNK的提高以及磷酸化MAPKs的水平.而且,Verbascoside抑制RANKL诱导的NF-κB DNA结合的活化[1].
参考文献：
[1] Lee SY1, Lee KS, Yi SH, Kook SH, Lee JC. Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-κB pathway and attenuating ROS production. PLoS One. 2013 Dec 4;8(12):e80873. doi: 10.1371/journal.pone.0080873. eCollection 2013
| Storage | Store at -20°C |
| M.Wt | 624.59 |
| Cas No. | 61276-17-3 |
| Formula | C29H36O15 |
| Solubility | insoluble in H2O; ≥30.95 mg/mL in DMSO; ≥63.6 mg/mL in EtOH |
| Chemical Name | [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| SDF | Download SDF |
| Canonical SMILES | CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
