Tranylcypromine hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Tranylcypromine,也称作2-PCPA,是一种单胺氧化酶抑制剂(MAOI),不可逆地抑制MAO A和MAO B,抑制常数Ki值分别为101.9 μM和16 μM,半数最大抑制浓度IC50值分别为2.3 μM和0.95 μM[1].
Tranylcypromine也可以时间依赖和基于机制的方式有效且不可逆地抑制组蛋白去甲基化酶赖氨酸特异性去甲基化酶1(LSD1),Ki值和IC50值分别为242 μM和20.7 μM.LSD1是一种MAO的胺氧化酶同系物,与MAO A和B的催化位点具有相似性[1].
参考文献：
[1] Schmidt DM, McCafferty DG. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 2007 Apr 10;46(14):4408-16. Epub 2007 Mar 17.
| Physical Appearance | A solid |
| Storage | Desiccate at RT |
| M.Wt | 169.65 |
| Cas No. | 1986-47-6 |
| Formula | C9H11N·HCl |
| Solubility | ≥54.3 mg/mL in H2O; ≥54.9 mg/mL in EtOH; ≥7.8 mg/mL in DMSO |
| Chemical Name | (1R,2S)-2-phenylcyclopropanamine hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | N[C@H]1[C@H](C2=CC=CC=C2)C1.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
相关生物数据
