SR-3677
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SR-3677是新型的\有效的和高选择性的Rho激酶(ROCK-II)抑制剂.在基于酶与细胞的试验中,其IC50值约为0.3 nM[1].
据报道,SR-3677选择性地抑制ROCK-II,对ROCK-II\ppMLC\ROCK-I\PKA\MRCK和Akt1的IC50值分别为~ 3 nM\~3 nM\56 nM\3.968 μM\1.190 μM和7.491 μM.在对接实验中,SR-3677具有多个关键结合元件,从而显示出较高的效力与选择性.此外,在药理学研究中,SR-3677有效地促进房水外流以及调节靶点.
参考文献：
[1] Feng Y1, Yin Y, Weiser A, Griffin E, Cameron MD, Lin L, Ruiz C, Schürer SC, Inoue T, Rao PV, Schrter T, Lograsso P. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5. doi: 10.1021/jm800986w. Epub 2008 Oct 4.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 408.45 |
| Cas No. | 1072959-67-1 |
| Formula | C22H24N4O4 |
| Solubility | Soluble in DMSO |
| Chemical Name | N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)C3COC4=CC=CC=C4O3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
相关生物数据
