Ulipristal
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ulipristal是一种新型选择性孕激素受体调节剂(SPRM),用于在无防护性交或避孕失败后进行紧急避孕。Ulipristal可用于治疗良性妇科病症,如子宫肌瘤[1]。选择性孕酮受体调节剂(SPRM)代表作用于孕酮受体的一类新型试剂。SPRM涉及对各种孕酮靶组织施用临床相关的组织选择性孕酮激动剂、拮抗剂或混合的激动剂/拮抗剂[2]。
体外实验:在人精子中,大于等于0.4 μM的Ulipristal醋酸盐以剂量依赖的方式抑制孕酮诱导的顶体反应、超活化和[Ca2+]i。Ulipristal醋酸盐通过作为孕酮拮抗剂调节人类精子功能[3]。
在体实验:在末端脱氧核苷酸转移酶介导的dUTP切口标记测定中,与未治疗的肌瘤相比,UPA治疗的肌瘤细胞死亡增加[4]。
临床试验:在性交的120小时内使用UPA似乎是紧急避孕(EC)的合理可耐受以及有效的方法。在无保护性交后的前72小时内,UPA与LNG一样有效[1]。
参考文献:
[1]. Richardson A R, Maltz F N. Ulipristal acetate: review of the efficacy and safety of a newly approved agent for emergency contraception[J]. Clinical therapeutics, 2012, 34(1): 24-36.
[2]. Chwalisz K, Perez M C, DeManno D, et al. Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis[J]. Endocrine reviews, 2005, 26(3): 423-438.
[3]. Ko J K Y, Huang V W, Li R H W, et al. An in vitro study of the effect of mifepristone and ulipristal acetate on human sperm functions[J]. Andrology, 2014, 2(6): 868-874.
[4]. Courtoy G E, Donnez J, Marbaix E, et al. In vivo mechanisms of uterine myoma volume reduction with ulipristal acetate treatment[J]. Fertility and sterility, 2015, 104(2): 426-434. e1.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 433.58 |
Cas No. | 159811-51-5 |
Formula | C28H35NO3 |
Solubility | ≥21.7 mg/mL in DMSO; insoluble in H2O; ≥19.73 mg/mL in EtOH with ultrasonic |
Chemical Name | [(8S,11R,13S,14S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate |
SDF | Download SDF |
Canonical SMILES | CC(=O)C1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)OC(=O)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
细胞实验 [1]: | |
细胞系 |
精子 |
制备方法 |
在DMSO中的溶解度大于21.7 mg/mL。若配制更高浓度的溶液,一般步骤如下:请将试管置于37 °C加热10分钟和/或将其置于超声波浴中震荡一段时间。原液于-20 °C可放置数月。 |
反应条件 |
0.04、0.4、4和40 μM |
实验结果 |
在孕激素刺激的精子中,Ulipristal (≥ 0.4 μM) 呈剂量依赖性地降低顶体反应和超活化。在0.4 μM剂量下,Ulipristal将出现顶体反应和超活化(由孕酮诱导)的精子的百分比降低了33.1 ± 7.3%和55.3 ± 16.2%。 |
References: [1]. Ko J K Y, Huang V W, Li R H W, et al. An in vitro study of the effect of mifepristone and ulipristal acetate on human sperm functions[J]. Andrology, 2014, 2(6): 868-874. |
质量控制和MSDS
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