SB505124
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SB505124是一种转化生长因子β I型受体ALK4\ALK5和ALK7的选择性小分子抑制剂,对ALK4和ALK5的IC50值分别为129 ± 11 nM和47 ± 5 nM[1].
据报道,SB505124是ALK4\ALK5和ALK7对其底物Smad3的体外激酶活性的有效抑制剂.除此之外,SB505124也是可逆的ATP竞争性抑制剂.而且,用SB505124以100 μM的浓度处理48 h,对肾上皮A498细胞并没有显示出毒性.而且已被证实,SB505124在三种细胞系(HepG2人肝癌细胞\C2C12小鼠成肌细胞\Mv1Lu水貂肺细胞)中,可以浓度依赖的方式限制TGF-β诱导的Smad2磷酸化作用[1].
参考文献：
[1] DaCosta Byfield S1, Major C, Laping NJ, Roberts AB. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2004 Mar;65(3):744-52.
| Storage | Store at -20°C |
| M.Wt | 335.4 |
| Cas No. | 694433-59-5 |
| Formula | C20H21N3O2 |
| Solubility | ≥33.5 mg/mL in DMSO; ≥14.93 mg/mL in EtOH; ≥2.18 mg/mL in H2O with gentle warming and ultrasonic |
| Chemical Name | 2-[4-(1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
