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Ro 08-2750

现货
Catalog No.
B6996
神经生长因子(NGF)拮抗剂
组合的产品项目
规格价格库存 数量
1mg
¥ 2,128.00
Ship with 10-15 days

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Background

IC50: 1 μM (binds to NGF) [1]

Ro 08-2750 is an antagonist of nerve growth factor (NGF), which selectively inhibits binding to p75NTR over TRKA147. This selectivity was used to study the functions of p75NTR and TrkA in apoptosis, neuronal differentiation and neurite outgrowth. NGF is a neuropeptide mainly involved in the regulation of growth, proliferation, maintenance, and survival of certain target neurons.

In vitro: Ro 08-2750 can bind to the NGF dimer with ~ 1:1 binding ratio. Binding of Ro 08-2750 to NGF induces NGF a concentration-dependent conformational change [1]. Binding with low concentration of Ro 08-2750, NGF can no longer bind to p75NTR anymore, however, binding to TrkA is not impaired. At higher concentrations of Ro 08-2750 more than 5 mM, the NGF/Ro 08-2750 complex can not bind to TrkA as well. In SK-N-MC cells, Ro 08-2750 leads to inhibition of NGF-induced programmed cell death. In PC12 cells, Ro 08-2750 can enhance the signal pathway through TrkA[2].

In vivo:. So far, in vivo study has been conducted.

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Arkin MR, Wells JA.  Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov. 2004 Apr;3(4):301-17.
[2] Niederhauser O, Mangold M, Schubenel R, Kusznir EA, Schmidt D, Hertel C.  NGF ligand alters NGF signaling via p75(NTR) and trkA. J Neurosci Res. 2000 Aug 1;61(3):263-72.

Chemical Properties

Physical AppearanceOrange solid
StorageStore at -20°C
M.Wt270.24
Cas No.37854-59-4
FormulaC13H10N4O3
Solubility<2.7mg/ml in DMSO
Chemical Name7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde
SDFDownload SDF
Canonical SMILESO=C1NC(N=C2N(C)C3=CC(C=O)=C(C)C=C3N=C21)=O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

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批次:

化学结构

Ro 08-2750