Perindopril
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Perindopril是血管紧张素I转换酶(ACE)的抑制剂[1].
在肝癌细胞中,Perindopril作为ACE的抑制剂,抑制肿瘤生长和血管生成,具有抗癌活性.在体外细胞增殖试验中,Perindopril对细胞增殖无显著影响.然而,在KB细胞中,低至1 μM的Perindopril也可以显著降低VEGF的mRNA表达,并能够抑制VEGF启动子的诱导活性.此外,在KB细胞中,1 μM Perindopril可以显著抑制血管紧张素II的产生.体内试验表明,Perindopril可以抑制SCC-VII细胞生长[1].据报道,口服8mg Perindopril可以降低血压而不影响心率[1,2].
参考文献：
[1] Ryuji Yasumatsu, Torahiko Nakashima, Muneyuki Masuda, Aya Ito, Yuichiro Kuratomi, Yuichiro Kuratomi and Shizuo Komune. Effects of the angiotensin-I converting enzyme inhibitor perindopril on tumor growth and angiogenesis in head and neck squamous cell carcinoma cells. J Cancer Res Clin Oncol. 2004, 130: 567–573.
[2] A. A.Ajayi, K.R.Lees and J.L.Reid. Effects of angiotensin converting enzyme inhibitor, perindopril, on autonomic reflexes. Eur J Clin Pharmacol. 1986, 30:177-182.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 368.47 |
| Cas No. | 82834-16-0 |
| Formula | C19H32N2O5 |
| Solubility | Soluble in DMSO |
| Chemical Name | (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
