Pantoprazole
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Pantoprazole是一种H+/K+-ATPase抑制剂[1].
Pantoprazole可抑制胃粘膜壁细胞中H+/K+-ATPase质子泵的活性.这一抑制效果可影响酸分泌,因此pantoprazole可用作治疗多种酸相关失调的药物.Pantoprazole可缓慢活化.活化的pantoprazole磺胺可结合质子泵的Cys813和Cys822,选择性地抑制酸分泌.Pantoprazole可抑制溶酶体酸化,IC50值为194 μM.Pantoprazole的pKa值为3.83(pKa1)和0.11(pKa2).此外,pantoprazole对幽门螺杆菌也具有抗菌功能[1,2].
参考文献：
[1] Jungnickel P W. Pantoprazole: a new proton pump inhibitor. Clinical therapeutics, 2000, 22(11): 1268-1293.
[2] Sachs G, Shin J M, Howden C W. Review article: the clinical pharmacology of proton pump inhibitors. Alimentary pharmacology & therapeutics, 2006, 23(s2): 2-8.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 383.37 |
| Cas No. | 102625-70-7 |
| Formula | C16H15F2N3O4S |
| Solubility | ≥17.95 mg/mL in DMSO; ≥29.05 mg/mL in EtOH; ≥4.17 mg/mL in H2O |
| SDF | Download SDF |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
