NSC 207895 (XI-006)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NSC 207895是一种小分子的MDMX抑制剂，GI50值为117 nM[1]。
NSC 207895是一种毒性较低的苯并呋喃衍生物。NSC 207895可降低MDMX启动子的活性，进而在MCF-7细胞中降低MDMX的mRNA和蛋白水平。其对MDMX的抑制与活化p53同时进行。NSC 207895可在MCF-7细胞中诱导促凋亡基因的表达，诱发细胞凋亡。PARP的剪切是由NSC 207895显著诱导的[2]。
NSC 207895也是一种DNA损伤剂。该物质对DNA修复和复制叉复合体都有强烈的功能性相互作用。NSC 207895激活DNA损伤应答（DDR），并引发细胞周期进程延迟[3]。
参考文献：
[1] Hawes JJ, Nerva JD, Reilly KM. Novel dual-reporter preclinical screen for antiastrocytoma agents identifies cytostatic and cytotoxic compounds. J Biomol Screen. 2008 Sep;13(8):795-803.
[2] Wang H, Ma X, Ren S, Buolamwini JK, Yan C. A small-molecule inhibitor of MDMX activates p53 and induces apoptosis. Mol Cancer Ther. 2011 Jan;10(1):69-79.
[3] Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451.
| Storage | Store at -20°C |
| M.Wt | 279.25 |
| Cas No. | 58131-57-0 |
| Formula | C11H13N5O4 |
| Solubility | Limited solubility |
| Chemical Name | 4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium |
| SDF | Download SDF |
| Canonical SMILES | CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | NSC 207895是一种抗癌制剂。 | |||||
| 靶点 | E3 ligase MDM2 | MDMX | ||||
| IC50 | ||||||
化学结构
