Meisoindigo
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Meisoindigo是治疗急性髓性白血病的潜在药物[1].
Meisoindigo是indirubin的合成修饰物.Meisoindigo在中国已被用于慢性髓性白血病的治疗,毒性很小.在体外试验中,可抑制DNA和RNA合成,以及微管组装.也有报道meisoindigo对急性髓性白血病也有效.在AML细胞系HL-60\NB4和U937中,meisoindigo 以caspase依赖和非依赖的途径诱导细胞凋亡.Meisoindigo可能通过内在线粒体途径而介导上述效应.Meisoindigo也诱导细胞周期阻滞,导致sub-G1和G0/G1期细胞数量增加,S期细胞数量减少.此外,研究发现,meisoindigo 诱导HL-60和NB4细胞系的分化.Meisoindigo可下调hTERT的表达,这可能加强化疗药物的抗白血病活性.此外,研究表明meisoindigo在植入AML细胞的NOD/SCID小鼠中显示出适中的抗肿瘤效应[1].
参考文献：
[1] Lee CC, Lin CP, Lee YL, Wang GC, Cheng YC, Liu HE. Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Leuk Lymphoma. 2010 May;51(5):897-905.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 276.29 |
| Cas No. | 97207-47-1 |
| Formula | C17H12N2O2 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic |
| Chemical Name | (3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one |
| SDF | Download SDF |
| Canonical SMILES | CN1C2=CC=CC=C2C(=C3C4=CC=CC=C4NC3=O)C1=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
