Icotinib
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Icotinib是一种有效的EGFR（表皮生长因子受体）酪氨酸激酶特异性抑制剂（IC50 = 5 nM）[1]。
EGFR属于受体酪氨酸激酶家族，是一种跨膜蛋白，参与调节细胞增殖、运动以及凋亡。EGFR表达于多种人类癌细胞，包括乳腺癌、头颈癌、NSCLC（非小细胞肺癌）以及卵巢癌[1]。
在人表皮样癌A431细胞系中，Icotinib呈剂量依赖性地抑制EGF诱导的EGFR磷酸化。Icotinib也抑制多种细胞内蛋白的酪氨酸磷酸化[1]。
在不同类型的肿瘤异种移植小鼠模型中，Icotinib呈剂量依赖性地抑制肿瘤生长，而不具有明显的体重减轻以及中毒迹象。一项随机、双盲、Gefitinib作为对照的多中心III期临床试验表明，Icotinib对晚期NSCLC有效[1]。
参考文献：
[1] Tan F, Shen X, Wang D, Xie G, Zhang X, Ding L, Hu Y, He W, Wang Y, Wang Y. Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies. Lung Cancer. 2012 May;76(2):177-82.
| Storage | Store at -20°C |
| M.Wt | 391.42 |
| Cas No. | 610798-31-7 |
| Formula | C22H21N3O4 |
| Solubility | insoluble in H2O; ≥129.6 mg/mL in DMSO; ≥14.13 mg/mL in EtOH with ultrasonic |
| Chemical Name | N-(3-ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine |
| SDF | Download SDF |
| Canonical SMILES | [H]C1=C2OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC2=C([H])C3=NC([H])=NC(N([H])C4=C([H])C([H])=C([H])C(C#C[H])=C4[H])=C31 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
