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Fumonisin B1

Fumonisin B1

伏马菌素B1

Catalog No.

A4537

PP5/PP2Cα/PP2A/PP1γ2/PP2B抑制剂

组合的产品项目
规格	价格	库存
1mg	￥ 1,408.00	Ship with 10-15 days
5mg	￥ 4,820.00	Ship with 10-15 days
10mg	￥ 8,016.00	Ship with 10-15 days

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背景
文献引用
化学属性
质量控制

背景

Mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC₅₀ ~ 75 nM). Also inhibits protein phosphatases; IC₅₀ values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.

文献引用

1. Liu XH, Liang S, et al. "Metabolomics Analysis Identifies Sphingolipids as Key Signaling Moieties in Appressorium Morphogenesis and Function in Magnaporthe oryzae." MBio. 2019 Aug 20;10(4). pii: e01467-19. PMID:31431550

化学属性

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	721.83
Cas No.	116355-83-0
Formula	C₃₄H₅₉NO₁₅
Solubility	Limited solubility, soluble in DMSO
Chemical Name	rac-(2R,2'R)-2,2'-((((5S,6S,7R,9R,11S,16S,18R,19R)-19-amino-11,16,18-trihydroxy-5,9-dimethylicosane-6,7-diyl)bis(oxy))bis(2-oxoethane-2,1-diyl))disuccinic acid
SDF	Download SDF
Canonical SMILES	C[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](OC(C[C@@H](C(O)=O)CC(O)=O)=O)[C@H](OC(C[C@@H](C(O)=O)CC(O)=O)=O)[C@H](C)CCCC
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