DOI hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
DOI hydrochloride is a brain-permeable agonist of 5-HT2A and 5-HT2C receptors, with Ki values being 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors, respectively. The 5-HT2 receptor consists of three distinct subpopulations, i.e. 5-HT2A, 5-HT2B, and 5-HT2C receptors, among which the 5-HT2A receptor contributes to the major part of the behavioral effects evoked by hallucinogens. DOI, as a phenylisopropylamine hallucinogen, can thus be used to explore 5-HT2 receptor mediated biological events due to its high affinity for the 5-HT2 receptor. In addition, DOI has also been used as an analytical reference standard categorized as a phenethylamine and amphetamine.
References:
1. Nelson DL, Lucaites VL, Wainscott DB, et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn-Schmiedeberg's Archives of Pharmacology, 1999, 359(1): 1-6.
2. Kerrigan S, Banuelos S, Perrella L, et al. Simultaneous detection of ten psychedelic phenethylamines in urine by gas chromatography-mass spectrometry. Journal of Analytical Toxicology, 2011, 35(7): 459-469.
3. Yu B, Becnel J, Zerfaoui M, et al. Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency. Journal of Pharmacology and Experimental Therapeutics, 327(2): 316-323.
4. Monti JM, Jantos H. Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat. European Journal of Pharmacology, 2006, 553(1-3): 163-170.
Physical Appearance | A crystalline solid |
Storage | Store at RT |
M.Wt | 357.62 |
Cas No. | 42203-78-1 |
Formula | C11H16INO2·HCl |
Solubility | Soluble in H2O |
Chemical Name | (S)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine hydrochloride |
SDF | Download SDF |
Canonical SMILES | IC1=C(C=C(C(OC)=C1)C[C@H](C)N)OC.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Cell experiment:[3] | |
Cell lines |
Rat aortic smooth muscle (RASM) cells |
Reaction Conditions |
1 nM DOI |
Applications |
DOI rapidly blocked TNF-α-induced ICAM1 expression in RASM cells. Moreover, the effect of DOI at blocking proinflammatory gene expression remained many hours after addition of TNF-α. |
Animal experiment:[4] | |
Animal models |
Male Wistar rats, 350–400 g |
Dosage form |
0.35 ~ 0.7 mmol/kg Subcutaneous administration |
Applications |
DOI significantly increased waking and light sleep, and reduced slow wave sleep, rapid-eye-movement (REM) sleep, and the number of REM periods in rats. |
Note |
The technical data provided above is for reference only. |
References: 1. Nelson DL, Lucaites VL, Wainscott DB, et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn-Schmiedeberg's Archives of Pharmacology, 1999, 359(1): 1-6. 2. Kerrigan S, Banuelos S, Perrella L, et al. Simultaneous detection of ten psychedelic phenethylamines in urine by gas chromatography-mass spectrometry. Journal of Analytical Toxicology, 2011, 35(7): 459-469. 3. Yu B, Becnel J, Zerfaoui M, et al. Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency. Journal of Pharmacology and Experimental Therapeutics, 327(2): 316-323. 4. Monti JM, Jantos H. Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat. European Journal of Pharmacology, 2006, 553(1-3): 163-170. |
质量控制和MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)