Clemizole hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NS4B蛋白在HCV(丙型肝炎病毒)复制中发挥重要作用。扰乱NS4B功能是一种新的抗HCV策略。与单独使用一种抗病毒药物相比,Clemizole与其它抗HCV药物的共同使用可增加抗病毒效果,并降低病毒耐药性的出现。
体外实验:Clemizole的抗病毒效果比较温和,对于 HCV基因型2a克隆,8 mM clemizole可发挥50%的抗病毒效果。其与HCV蛋白酶抑制剂VX950和SCH503034有高度协同的抗病毒效果,且没有毒性。与此相反,clemizole与干扰素、利巴韦林、核苷(NM283)和非核苷(HCV796)HCV聚合酶抑制剂的共同使用可产生加和的药物效果[1]。
在体实验:在C57BL / 6J小鼠中,Clemizole具有较短的血浆半衰期,可迅速地转化为葡糖苷酸(M14)和脱烷基化代谢物(M12)以及多种较小的代谢产物[2]。
临床试验:研究的目的是测试未接受治疗的HCV患者感染中 clemizole hydrochloride的安全性和耐受性。主要用于研究clemizole hydrochloride对病毒和身体的影响。
参考文献:
[1] Einav S, Sobol HD, Gehrig E, Glenn JS.? The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010;202(1):65-74.?
[2] Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, Liu M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Nakamura M, Nomura T, Chen Y, Zheng M, Fitch WL, Peltz G.? Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013;344(2):388-96. doi: 10.1124/jpet.112.198697. Epub 2012 Nov 8.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 362.3 |
Cas No. | 1163-36-6 |
Formula | C19H21Cl2N3 |
Solubility | ≥15.13 mg/mL in EtOH with gentle warming and ultrasonic; ≥18.12 mg/mL in DMSO; ≥5.12 mg/mL in H2O with gentle warming and ultrasonic |
Chemical Name | 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;hydrochloride |
SDF | Download SDF |
Canonical SMILES | C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
描述 | Clemizole hydrochloride是H1组胺受体的拮抗剂,IC50值为8 mM。 | |||||
靶点 | NS4B | HCV(Hepatitis C Virus) | ||||
IC50 | 8 mM |
质量控制和MSDS
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