Cinnamycin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cinnamycin is a tricyclic antibiotic.
Cinnamycin, a tetracyclic lantibiotic, is produced from S. cinnamoneus containing four unusual amino acids: mesolanthionine, erythro-β-hydroxyaspartic acid, threo-β-methyllanthionine and lysinoalanine.
In vitro: A previous study indicated that cinnamycin could exclusively bind to ethanolamine phospholipids, such as PE and ethanolamine plasmalogen. Model membrane study showed that the binding of cinnamycin to PE-containing liposomes was dependent on membrane curvature. The binding of cinnamycin to multilamellar liposomes induced tubulation of membranes, as demonstrated by electron microscopy and small-angle x-ray scattering [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: A retrospective survey of patients treated with clindamycin for a soft tissue infection was conducted to evaluated whether the incidence of serious side effects was sufficient to preclude the use of this antibiotic. Thirteen patients were found to have severe diarrhoea and 2 of these required inpatient treatment. Certain limitations of the use of clindamycin were suggested but, it was concluded that cinnamycin still has a useful role to play in the treatment of acute soft tissue infection [2].
References:
[1] Iwamoto K, Hayakawa T, Murate M, Makino A, Ito K, Fujisawa T, Kobayashi T. Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin. Biophys J. 2007 Sep 1;93(5):1608-19.
[2] Wilson DH. Clindamycin in the treatment of soft tissue infections: a review of 15 019 patients. Br J Surg. 1980 Feb;67(2):93-6.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 2041.3 |
| Cas No. | 110655-58-8 |
| Formula | C89H125N25O25S3 |
| Synonyms | Lanthiopeptin,NSC 71936,Ro 09-0198 |
| Solubility | Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide |
| Chemical Name | L-cysteinyl-L-arginyl-L-glutaminyl-D-cysteinyl-L-cysteinyl-3-aminoalanyl-L-phenylalanylglycyl-L-prolyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-L-valyl-L-cysteinyl-(3R)-3-hydroxy-L-a-aspartylglycyl-L-asparaginyl-(2S,3S)-2-amino-3-m |
| SDF | Download SDF |
| Canonical SMILES | O=C([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@@H]([C@H](C)SC[C@H](NC([C@H](N2)CSC3)=O)C4=O)NC([C@H](CC5=CC=CC=C5)NC([C@H]6N(C(CNC([C@@H](NC([C@H](CNCCCC[C@@H](C(O)=O)N7)N4)=O)CC8=CC=CC=C8)=O)=O)CCC6)=O)=O)=O)=O)N[C@@H]3C(N[C@@H]([C@@H](O)C(O)=O)C(NCC(N |
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