Eugenol
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Eugenol是一种苯丙素类化合物,是从某些精油如丁香油、肉桂、肉豆蔻、罗勒和月桂叶提取的一种无色至浅黄色油状液体。
体外:先前研究表明,eugenol可以消耗细胞内GSH,抑制GJIC和ROS的产生,并且10至100 μM浓度的eugenol对MMP具有适度的作用。高浓度的eugenol也能够影响Ca2+、PMP,以及pH。对GSH水平和GJIC的作用是最早研究发现并且是最强效的。此外,与谷胱甘肽乙酯联合给药将细胞内GSH水平提高了接近100%,并且完全保护细胞免于由eugenol引起的细胞死亡。这些结果表明,eugenol主要通过中断硫醇依赖性过程和耗尽细胞保护性硫醇表现出肝毒性效应[1]。
体内:动物研究表明,在吲哚美辛给药之前1小时用单剂量的eugenol进行预处理会引起胃酸输出、胃粘膜损伤以及胃蛋白酶活性的显著降低,而粘蛋白浓度明显增加。此外,eugenol还可以显著减弱胃粘膜丙二醛和总亚硝酸盐的升高[2]。
临床试验:已进行临床研究以评价氧化锌丁香酚和metapex对根管治疗原发牙的作用。结果表明,氧化锌丁香酚和metapex都有令人鼓舞的结果,然而,当对患者进行随访时,metapex在使用方面更加安全[3]。
参考文献:
[1] Thompson DC,Barhoumi R,Burghardt RC. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol.1998 Mar;149(1):55-63.
[2] Morsy MA,Fouad AA. Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother Res.2008 Oct;22(10):1361-6.
[3] Gupta S,Das G. Clinical and radiographic evaluation of zinc oxide eugenol and metapex in root canal treatment of primary teeth. J Indian Soc Pedod Prev Dent.2011 Jul-Sep;29(3):222-8.
Storage | Store at -20°C |
M.Wt | 164.2 |
Cas No. | 97-53-0 |
Formula | C10H12O2 |
Solubility | insoluble in H2O; ≥59.2 mg/mL in DMSO; ≥62.2 mg/mL in EtOH |
Chemical Name | 4-allyl-2-methoxyphenol |
SDF | Download SDF |
Canonical SMILES | C=CCC1=CC(OC)=C(O)C=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
- 批次: