STF-62247
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
STF-62247可在野生型VHL和VHL缺失的肾细胞癌(RCC)中以HIF不依赖的方式抑制肿瘤生长,IC50值分别为16 μM和0.625 μM.
von Hippel-Lindau(VHL)肿瘤抑制基因的失活可导致大量肾细胞癌(RCC),且与高度血管化和不良预后紧密相关.STF-62247在体外和体内对VHL缺失细胞具有选择性细胞毒性.[1]
体外实验:体外研究证明,STF-62247以HIF不依赖的方式对野生型VHL和VHL缺失的肾细胞癌(RCC)具有选择性细胞毒性和肿瘤生长抑制活性,IC50值分别为16 μM和0.625 μM.此外,STF-62247也可在VHL缺失的细胞中诱导酸化和增加自噬,从而导致细胞凋亡.[1]
体内实验:用于研究STF-62247活性的动物实验遵循机构和国家的指导方针,由斯坦福大学实验动物保护管理专家组批准.基于体内小鼠模型发现,腹腔内注射剂量为8 mg/kg的STF-62247可显著抑制VHL缺失SN12C肿瘤细胞的肿瘤生长.[1]
临床试验:迄今为止尚未进行临床试验.
参考文献：
[1]Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA and Giaccia AJ. A molecule targeting vhl-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 2008 Jul; 14: 90-102.
| Storage | Store at -20°C |
| M.Wt | 267.35 |
| Cas No. | 315702-99-9 |
| Formula | C15H13N3S |
| Solubility | insoluble in H2O; ≥2.31 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO |
| Chemical Name | N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
