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DL-threo-2-methylisocitrate sodium

现货
Catalog No.
B1310
异柠檬酸裂合酶1(ICL1)底物
组合的产品项目
规格价格库存 数量
1000mg
¥ 88,880.00
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Background

DL-threo-2-methylisocitrate sodium is a substrate of isocitratelyase 1(ICL1).

ICL1 had dual activity for both threo-D(s)L(s)-isocitrate (ICA) and DL-threo-2-methylisocitrate (MICA). Using Michaelis-Menten non-linear least squares fit, the Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 mM with akcatof 5.24 s-1 .The Km of ICL2 for MICA was greater than 15 mM which was too high to be determained accurately due to the limitations of the solubility of MICA. The Kcat/Km for ICL1, a measureforcatalyticefficiency, was 2.79 × 104 M-1 s-1 and 1.74 ×103 M-1 s-1, for ICA and MICA respectively.

Reference:
[1].  Gould TA1,van de Langemheen H,Muoz-Elías EJ,McKinney JD,Sacchettini JC. Dual role of isocitratelyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.Mol Microbiol.2006 Aug;61(4):940-7.

Chemical Properties

StorageStore at -20°C
M.Wt544.19
FormulaC14H14Na6O14
SolubilitySoluble in DMSO
Chemical Namesodium (2R,3S)-3-hydroxybutane-1,2,3-tricarboxylate
SDFDownload SDF
Canonical SMILESC[C@](C([O-])=O)(O)[C@@](C([O-])=O)([H])CC([O-])=O.C[C@](C([O-])=O)(O)[C@@](C([O-])=O)([H])CC([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

质量控制和MSDS

批次:

化学结构

DL-threo-2-methylisocitrate sodium