Letermovir
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AIC246,也被称为Letermovir,是新型的抗巨细胞病毒化合物,其IC50值为5.1 ± 1.2 nM。AIC246靶向病毒末端酶复合物的pUL56(氨基酸230 ~ 370)亚基[1]。
pUL56亚基是末端酶复合物的组分,将单位长度的DNA导入组装中的病毒粒子。
AIC246具有新型的作用机制,靶向UL56末端酶并对其它耐药性病毒有效。使用各种人巨细胞病毒实验株和耐GCV病毒对AIC246的抗人巨细胞病毒活性进行体外评价。结果表明,AIC246的抑制作用比目前“黄金标准”GCV的强400多倍(EC50值分别为~ 4.5 nM和~ 2 μM),而关于EC90值(6.1 nM对14.5 μM),其效力比GCV的高2000多倍。在CPE-RA菌株中,AIC246的EC50值范围为1.8 nM ~ 6.1 nM[2]。
在人巨细胞病毒皮下异种移植小鼠模型中,口服给予AIC246呈剂量依赖性地显著降低人巨细胞病毒滴度。30 mg/kg/d的AIC2469,持续9天,与“黄金标准”GCV相比,在ED50和ED90水平下可以最大程度地减少噬斑形成单位数[2]。
参考文献:
[1]. Verghese PS, Schleiss MR. Letermovir Treatment of Human Cytomegalovirus Infection Anti-infective Agent. Drugs Future. 2013, 38(5):291-298.
[2]. Lischka P1, Hewlett G, Wunberg T, et al.In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.Antimicrob Agents Chemother. 2010, 54(3):1290-1297.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 572.55 |
Cas No. | 917389-32-3 |
Formula | C29H28F4N4O4 |
Synonyms | AIC246;AIC 246;AIC-246 |
Solubility | ≥57.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
Chemical Name | 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid |
SDF | Download SDF |
Canonical SMILES | COC1=C(C=C(C=C1)C(F)(F)F)N2C(C3=C(C(=CC=C3)F)N=C2N4CCN(CC4)C5=CC(=CC=C5)OC)CC(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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