C 021 dihydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
C 021 dihydrochloride是CCR4的强效拮抗剂,对小鼠和人趋化性抑制的IC50值分别为0.039和0.14 μM[1].
CC趋化因子受体4(CCR4)是G蛋白偶合受体,是CC趋化因子的受体,在免疫系统的发育和功能中起重要作用.
C 021 dihydrochloride是一种有效的CCR4拮抗剂.C 021 dihydrochloride有效抑制小鼠和人的趋化功能,IC50值分别为0.039和0.14 μM.在GTPγS结合实验中,C 021 dihydrochloride的IC50值为0.018 μM[1].
使用氧化偶氮甲烷(AOM)处理小鼠,诱发肝性脑病,AOM显著增加小胶质细胞活化和肝脏\血清和皮质中CCL2的浓度.C 021 dihydrochloride减少肝损伤,显著改善神经功能.C 021 dihydrochloride降低小胶质细胞活化和ERK1/2的磷酸化,抑制AOM诱导的细胞因子上调[2].
参考文献：
[1]. Yokoyama K, Ishikawa N, Igarashi S, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem, 2009, 17(1): 64-73.
[2]. McMillin M, Frampton G, Thompson M, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation, 2014, 11: 121.
| Physical Appearance | Pale yellow solid |
| Storage | Store at -20°C |
| M.Wt | 540.57 |
| Cas No. | 864289-85-0 |
| Formula | C27H41N5O2·2HCl |
| Solubility | Soluble in DMSO |
| Chemical Name | 2-([1,4'-bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | COC1=CC2=C(N=C(N=C2N(C3CCCCCC3)[H])N4CCC(CC4)N5CCCCC5)C=C1OC.Cl.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
