BMS 193885
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BMS-193885是有效的神经肽Y1受体选择性拮抗剂，IC50值为5.9 nM。
神经肽Y受体1是G蛋白偶联受体，参与调节食物摄取与能量平衡。神经肽Y1在包括海马体、下丘脑、扁桃体和大脑皮层以及外周组织心脏、肾脏、骨骼肌在内的多种组织中均有表达。其定位和表达表明其参与调控食物摄取和体重。
在细胞培养物中，用表达人类Y(1)受体的CHO细胞进行的毛喉素刺激c-AMP产生实验中，BMS-193885显示出对神经肽Y1的功能拮抗作用。
在体内，在大鼠中使用剂量为10 mg/kg的BMS-193885可导致1h的神经肽Y诱导的食物摄取和自发的过夜食物消耗[2]。相比对照组未出现耐受或影响水摄取，长期使用BMS-193885（10 mg/kg）i.p.到44天，可显著降低食物摄取和体重增长速率[2]。
参考文献：
1. Poindexter GS, Bruce MA, LeBoulluec KL, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorganic & medicinal chemistry letters. 2002;12(3):379-382.
2. Antal-Zimanyi I, Bruce MA, Leboulluec KL, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. European journal of pharmacology. 2008;590(1-3):224-232.
| Physical Appearance | Pale yellow solid |
| Storage | Desiccate at RT |
| M.Wt | 680.79 |
| Cas No. | 679839-66-8 |
| Formula | C33H42N4O6·C3H6O3 |
| Solubility | <68.08mg/ml in DMSO; <13.62mg/ml in H2O |
| Chemical Name | (S)-2-hydroxypropanoic acid compound with (Z)-N-(3-(3,5-bis(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenyl)-N'-(3-(4-(3-methoxyphenyl)piperidin-1-yl)propyl)carbamimidic acid (1:1) |
| SDF | Download SDF |
| Canonical SMILES | CC(N1)=C(C(OC)=O)C(C(C(OC)=O)=C1C)C2=CC(N/C(O)=N/CCCN3CCC(C4=CC(OC)=CC=C4)CC3)=CC=C2.C[C@@](O)([H])C(O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
