BI 78D3
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BI-78D3是JNK的底物竞争性抑制剂[2]。
JNK是MAPK家族的成员。JNK是压力激活的蛋白激酶，可调节参与多个疾病状态的通路。非肌肉运动的JNK功能在多种细胞类型和器官中可能不同。JNK参与a1-肾上腺素受体介导的前列腺平滑肌收缩。对非恶性人类前列腺上皮细胞，JNK激活不仅具有促凋亡和抗增殖功能，还与JNK依赖的存活有关。[1]
BI-78D3可与ATF2竞争结合JNK1，Ki值为200 nM。此外，BI-78D3不可抑制缺少D结构域的短肽底物的磷酸化。这表明BI-78D3是底物竞争性的。[2]
BI-78D3可抑制去甲肾上腺素和苯肾上腺素诱导的收缩。该物质可阻止α1-肾上腺素受体介导的前列腺组织收缩。作为一种有效的JNK抑制剂，BI-78D3具有消除ConA诱导的肝损伤和恢复胰岛素敏感性的能力。[1,2]
参考文献：
[1] Strittmatter F1, Walther S, Gratzke C, etal. , Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c-Jun N-terminal kinase, SP600125 and BI-78D3. Br J Pharmacol. 2012 Jul;166(6):1926-35.
[2] Stebbins JL, De SK, Machleidt T,etal. , Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 379.37 |
| Cas No. | 883065-90-5 |
| Formula | C13H9N5O5S2 |
| Solubility | Soluble in DMSO |
| Chemical Name | 4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-((5-nitrothiazol-2-yl)thio)-4H-1,2,4-triazol-3-ol |
| SDF | Download SDF |
| Canonical SMILES | OC1=NN=C(SC2=NC=C(S2)N(=O)=O)N1C3=CC4=C(OCCO4)C=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
