AZ 11645373
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AZ11645373是一种高选择性的和有效的人类P2X7受体拮抗剂，对小鼠/大鼠P2X7受体无效。
腺苷5’-三磷酸（ATP）门控的P2X受体（P2XR）由编码胞质膜钙阳离子离子通道的七个基因组成。这些蛋白在自发、感觉和中枢神经元及内脏平滑肌、上皮和免疫细胞中具有不同的表达。P2XR在急性和/或慢性痛觉中也有潜在作用。
在细胞培养物中，使用AZ11645373可在HEK细胞中以不可克服的方式抑制人类P2X7受体响应，KB值范围为5-20 nM[1]。KB值在去除胞外钙和镁时仍未改变。此外，在脂多糖活化的THP-1细胞中，AZ11645373处理可抑制ATP诱发的IL-1β释放，IC50值为90 nM[1]。
为研究AZ11645373的体内效果，人类或小鼠或其他动物模型中的实验仍待进行。
参考文献：
1. Stokes L, Jiang LH, Alcaraz L, et al. Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373. British journal of pharmacology. 2006;149(7):880-887.
| Physical Appearance | Off White solid |
| Storage | Store at -20°C |
| M.Wt | 463.51 |
| Cas No. | 227088-94-0 |
| Formula | C24H21N3O5S |
| Solubility | insoluble in DMSO |
| Chemical Name | (R)-3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C1N(C(SC1)=O)[C@@H](COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC4=CC=NC=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
